Selectivity of a novel α1-adrenoceptor agonist, PNO-49B, for α1-adrenoceptor subtypes.
نویسندگان
چکیده
منابع مشابه
Functional role of α1-adrenoceptor subtypes in murine ophthalmic arteries.
PURPOSE To identify the α(1)-adrenoceptor (α(1)-AR) subtypes mediating vascular adrenergic responses in murine ophthalmic arteries. METHODS Expression of mRNA was quantified for individual α(1)-AR subtypes in murine ophthalmic arteries using real-time PCR. To assess the functional relevance of α(1)-ARs for mediating vascular responses, ophthalmic arteries from mice deficient in one of the thr...
متن کاملTheoretical proton affinities of α1 adrenoceptor ligands
A systematic study has been performed of the proton affinity of a large family of agonists and antagonists of the α1-adrenoceptor at the B3LYP/6-31G* level of theory. After a conformational search, all the N atoms were considered as protonation sites and protonation energy values were determined. The inclusion of solvation by means of the Onsager model yielded stabilization in the proton affini...
متن کاملRegression of Intracranial Meningioma during Treatment with α1-Adrenoceptor Blocker.
Background Regression of meningioma has been reported after hemorrhage or hormonal withdrawal. Here, we report a case of an incidentally diagnosed meningioma that regressed in association with α1-adrenoceptor antagonist. Case report A 59-year old male patient with an incidentally diagnosed lateral sphenoid wing meningioma was followed with serial magnetic resonance imaging. The tumor with a max...
متن کاملEffects of the α1-adrenoceptor agonist phenylephrine on SART stress-induced orthostatic hypotension in rats
BACKGROUND Specific alternation of rhythm in temperature (SART)-stressed rats, an animal model of autonomic imbalance, exhibit low blood pressure and tachycardia during consciousness and under anesthesia. In addition, these rats easily develop orthostatic hypotension (OH) as a response to postural manipulation. Hence, we studied the influence of the adrenalin α1-receptor agonist phenylephrine o...
متن کاملCONTRACTIONS DUE TO α-ADRENOCEPTOR AGONISTS ARE MEDIATED BY α1-ADRENOCEPTORS IN RAT CAROTID ARTERY
Some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. The purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artelY Male Wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51500-1